ing. Krista van Meijgaarden

Research Technician

Krista@lumc.nl orcid

orcid.org/0000-0003-2818-9805

Krista van Meijgaarden is working at the Leiden University Medical Center, The Netherlands. She received her bachelor degree in Biochemistry at the University of applied sciences in Delft, The Netherlands. She has a long standing track record in the department where she is currently pursuing her PhD (Leiden University Center for Infectious diseases ). Immunology has always been her interest with a focus on the cellular immunology of the host response in tuberculosis, from classical CD4 and CD8 T cells to non-classical HLA-E restricted T cells and from monocytes to B cells. Acknowledging the host defense system as a sum of parts from innate to adaptive immunity, she is now studying the role of antibodies in tuberculosis as they are still underestimated in the immune response against mycobacterium tuberculosis.

Publications

BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination.
van Meijgaarden KE, Li W, Moorlag SJCFM, Koeken VACM, Koenen HJPM, Joosten LAB, Vyakarnam A, Ahmed A, Rakshit S, Adiga V, Ottenhoff THM, Li Y, Netea MG, Joosten SA.

Nat Commun. 2024 Jan 2;15(1):114. doi: 10.1038/s41467-023-44252-5. PMID: 38167829; PMCID: PMC10761850.
Mycobacterial growth inhibition is associated with trained innate immunity.
Joosten SA, van Meijgaarden KE, Arend SM, Prins C, Oftung F, Korsvold GE, Kik SV, Arts RJ, van Crevel R, Netea MG, Ottenhoff TH.

Clin Invest. 2018 May 1;128(5):1837-1851. doi: 10.1172/JCI97508. Epub 2018 Apr 3. PMID: 29461976; PMCID: PMC5919803.

Groups: Functional immunology of infection and vaccine induced responses

ing. Krista van Meijgaarden

Publications

News

Annemieke Geluk awarded Eijkman medal 2026

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Groups

Functional immunology of infection and vaccine induced responses

The aim of our research group is to delineate host immune-responses towards mycobacteria to innovate diagnostic and vaccination strategies.

Systemic immunometabolism

Our research is centred on studying the immune regulation of metabolic homeostasis, especially the crosstalk between metabolic and immune cells within metabolic organs in cardiometabolic diseases and parasitic infections.

Immunodiagnostics of mycobacterial diseases

Our research focusses on prediction, diagnosis and improved treatment of leprosy and TB based on translation of immunological mechanisms to field applications using population studies worldwide.

Microbiome Systems Biology

We are a human microbiome research group aimed at gaining a better fundamental understanding of the human microbiome and exploring the clinical relevance of its complex interactions with the host using various systems biology approaches.

Experimental Bacteriology

Our research group is interested in fundamental and translational aspects of bacterial biology.

Virus-Host interactions and Antiviral Strategies

Our research group aims to develop antiviral strategies against (re)emerging viruses, including novel host-directed approaches.

Immune variation and vaccine hypo-responsiveness

Our research focuses on understanding the immune system of populations with varying degree of exposure to microorganisms and parasites, which can influence disease patterns and vaccine responsiveness across the globe.

Translational Parasitology

Our research tackles questions such as the development of a highly effective single-dose malaria vaccine and the increased understanding of natural and vaccine-induced immunity against helminth infections.

Transgenic parasites in malaria

Our research aims to develop innovative interventions against human malaria.

Cellular Immunometabolism

Our studies are aimed at understanding how cellular metabolism and the metabolic micro-environment controls the functional properties of immune cells in the context of infection, cancer and obesity.

Mucosal and systems immunology

Our aim is to understand how protective immunity is induced and maintained in the respiratory mucosa after infection and vaccination.

Coronaviruses and other nidoviruses

Understanding coronavirus molecular biology is central to antiviral drug discovery and pandemic preparedness.

Molecular Immunology

We aim to uncover the fundamental molecular principles that govern protective and long-lasting immunity to infectious diseases in humans.

Glycoscience and Helminth infections

The group focusses in particular on research and applications in helminth infections, with an emphasis on schistosomiasis.

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