dr. Andrew I. Morrison
Research
My research is focused on developing a nasal-chip for mucosal vaccine evaluation. This involves using a microfluidic device to generate an organ-on-chip model with three components: an primary epithelial cell barrier for vaccine delivery, a primary tonsil-derived model to mimic vaccine responses and interconnecting microfluidic channels to allow the flow of antigen-presenting cells. By exploring various vaccine formulations and analysing responses across different donors, we will understand how nasal vaccines stimulate mucosal immunity and how host factors influence these responses.
Curriculum Vitae
I obtained my PhD at the VUmc-side of Amsterdam UMC, The Netherlands, where I developed stromal-competent models of human lymph nodes in vitro (2020-2025).
Prior to this, I worked as an intern at Novartis in Basel, Switzerland, in the autoimmunity department. This was where I also performed a 1 year project during my intercalated Master’s degree from University of Aberdeen, Scotland UK, in Immunology & Pharmacology (2013-2018).
Publications
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A Sacrificial 3D Printed Vessel-on-Chip Demonstrates a Versatile Approach to Model Granulation Tissue.
Jäger J, Berger P, Morrison AI, Erfurth H, Thon M, Dehne EM, Gibbs S, Koning JJ
Adv Healthc Mater. 2025 Nov 21:e03081. doi: 10.1002/adhm.202503081.
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Integration of lymphatic vasculature to a human lymph node-on-chip enhances physiological immune properties.
Morrison AI, Jäger J, de Winde CM, Konijn T, Roest HP, van der Laan LJW, Gibbs S, Koning JJ, Mebius RE.
Mater Today Bio. 2025 Sep 22;35:102326. doi: 10.1016/j.mtbio.2025.102326. eCollection 2025 Dec.
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Functional organotypic human lymph node model with native immune cells benefits from fibroblastic reticular cell enrichment.
Morrison AI, Kuipers JE, Roest HP, van der Laan LJW, de Winde CM, Koning JJ, Gibbs S, Mebius RE.
Sci Rep. 2025 Apr 10;15(1):12233. doi: 10.1038/s41598-025-95031-9.
