Martin Larralde

PhD student

m.f.larralde[at]lumc.nl orcid

orcid.org/0000-0002-3947-4444

Martin studied Molecular Biology and Computer Science at the Ecole Normale Supérieure Paris-Saclay before pursuing a Master’s degree in Bioinformatics and Biostatistics at the Université Paris-Saclay. He joined the Zeller lab in 2019 to study the secondary metabolism of the human gut microbiome.

Martin is involved in functional annotation, more specifically in the discovery of biosynthetic gene clusters (BGCs). He spent most of his PhD developing GECCO, a computational tool for identifying novel BGCs in silico from genomic and metagenomic sequences.

In addition, he develops high-performance software for efficient analysis of biological data, contributing interfaces for popular bioinformatics tools such as Prodigal, HMMER, or developing new accelerated implementations of popular algorithms.

Links:

X (Twitter)

GitHub

Publications

Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer
Osswald A, Wortmann E, Wylensek D, et al

Gut Published Online First: 18 December 2025. doi: 10.1136/gutjnl-2024-332243
PyOrthoANI, PyFastANI, and Pyskani: a suite of Python libraries for computation of average nucleotide identity.
Larralde M, Zeller G, Carroll LM.

NAR Genomics and Bioinformatics, Volume 7, Issue 3, September 2025, lqaf095, https://doi.org/10.1093/nargab/lqaf095
Fast, flexible gene cluster family delineation with IGUA
Larralde M, Blom J, Gourlé H, Carroll LM, Zeller G.

bioRxiv 2025.05.15.654203; doi: https://doi.org/10.1101/2025.05.15.654203

More publications

Groups: Microbiome Systems Biology

Martin Larralde

Publications

News

Annemieke Geluk awarded Eijkman medal 2026

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Groups

Functional immunology of infection and vaccine induced responses

The aim of our research group is to delineate host immune-responses towards mycobacteria to innovate diagnostic and vaccination strategies.

Systemic immunometabolism

Our research is centred on studying the immune regulation of metabolic homeostasis, especially the crosstalk between metabolic and immune cells within metabolic organs in cardiometabolic diseases and parasitic infections.

Immunodiagnostics of mycobacterial diseases

Our research focusses on prediction, diagnosis and improved treatment of leprosy and TB based on translation of immunological mechanisms to field applications using population studies worldwide.

Microbiome Systems Biology

We are a human microbiome research group aimed at gaining a better fundamental understanding of the human microbiome and exploring the clinical relevance of its complex interactions with the host using various systems biology approaches.

Experimental Bacteriology

Our research group is interested in fundamental and translational aspects of bacterial biology.

Virus-Host interactions and Antiviral Strategies

Our research group aims to develop antiviral strategies against (re)emerging viruses, including novel host-directed approaches.

Immune variation and vaccine hypo-responsiveness

Our research focuses on understanding the immune system of populations with varying degree of exposure to microorganisms and parasites, which can influence disease patterns and vaccine responsiveness across the globe.

Translational Parasitology

Our research tackles questions such as the development of a highly effective single-dose malaria vaccine and the increased understanding of natural and vaccine-induced immunity against helminth infections.

Transgenic parasites in malaria

Our research aims to develop innovative interventions against human malaria.

Cellular Immunometabolism

Our studies are aimed at understanding how cellular metabolism and the metabolic micro-environment controls the functional properties of immune cells in the context of infection, cancer and obesity.

Mucosal and systems immunology

Our aim is to understand how protective immunity is induced and maintained in the respiratory mucosa after infection and vaccination.

Coronaviruses and other nidoviruses

Understanding coronavirus molecular biology is central to antiviral drug discovery and pandemic preparedness.

Molecular Immunology

We aim to uncover the fundamental molecular principles that govern protective and long-lasting immunity to infectious diseases in humans.

Glycoscience and Helminth infections

The group focusses in particular on research and applications in helminth infections, with an emphasis on schistosomiasis.

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